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The Bouxsein group employs a multidisciplinary strategy with state-of-the-art technologies to study the causes, detection and treatment of skeletal fragility. One in two women and one in five men over the age of 50 will suffer a fragility fracture in their remaining lifetime. Thus, our ultimate goal is to reduce the burden of fractures due to osteoporosis and other bone disorders.

We have several ongoing projects, including: 1) the evaluation of novel technologies for non-invasive or minimally-invasive assessment of bone fragility and fracture risk in osteoporosis and other diseases associated with skeletal fragility; 2) identification of the biomechanical factors that contribute to vertebral fractures; 3) identification of the key factors that influence musculoskeletal deterioration following reduced mechanical loading; 4) understanding how diet influences bone mass acquisition; and 5) evaluating the biomechanical effects of new therapies for osteoporosis and fracture healing.

The Bouxsein group includes biomechanical engineers and biologists, and we collaborate closely with molecular biologists, clinicians, imaging specialists, and musculoskeletal epidemiologists. We are funded by grants from the National Institute of Arthritis, Musculoskeletal and Skin Diseases, the National Institute on Aging, National Institute of Child Health and Development, and NASA.

News and Events:

May 2015
Congratulations to Alex Bruno for successfully defending his PhD thesis in the Harvard-MIT Health Sciences and Technology Program! Alex is moving to Philadelphia to start his new career at Exponent!

April 2015
Congratulations to the spine modeling team on the publication of their manuscript in the Journal of Biomechanical Engineering! The manuscript describes a new OpenSim model of the full thoracolumbar spine and rib cage. Here is a link to the paper

March 2015
Congratulations to Mary Bouxsein on becoming an AIMBE Fellow!

February 2015
We are seeking a postdoctoral fellow to participate in NIH-funded research related to musculoskeletal modeling & spine biomechanics. Please see the opportunites page for more details.

August 2014
Lab outing to see the Red Sox!!

RedSoxGame1 RedSoxGame2
RedSoxGame4 RedSoxGame3

July 2014
Congratulations to Rachel Ellman for successfully defending her PhD thesis in the Harvard-MIT Health Sciences and Technology Program! Rachel is setting off to LA to start her new career at SpaceX!

March 2014
Check out the Genes and Galaxies Symposium hosted by Harvard Medical School Department of Genetics.

March 2014
We have several undergraduate summer project opportunities. Please check the opportunities page for more info.

February 2014
New study shows that bones are incredibly cool: Link to study

December 2013
Congrats to Dennis Anderson for recieving an outstanding research award from the National Center for Simulation in Rehabilitation Research (NCSRR)!

November 2013
Congrats to Rachel Ellman for the best student poster at the annual meeting of the American Society for Gravitational and Space Research!

November 2013
Congrats to Alex Bruno for successfully defending his proposal for PhD research in the Harvard-MIT Health Sciences and Technology Program!

October 2013
New paper by Dennis Anderson and team on "CT-Based Muscle Attenuation and Electrical Impedance Myography as Indicators of Trunk Muscle Strength Independent of Muscle Size in Older Adults," appearing in the American Journal of Physical Medicine & Rehabilitation. Congrats Dennis!

October 2013
New paper by Rachel Ellman and team on the "Combined effects of botulinum toxin injection and hindlimb unloading on bone and muscle," appearing in Calcified Tissue International. Congrats Rachel!

August 2013
New paper in the JBMR by Alex Bruno and the Framingham team comparing vertebral size, bone density, and strength in 981 pairs of men and women from the Framingham Heart Study that were matched for age and areal spine BMD. Link to Paper

August 2013
Congratulations to Clara De Paolis who will be starting a graduate program in electrical engineering this fall at Tufts University!

August 2013
Congratulations to Dennis Anderson who was awarded a K99/R00 Pathway to Independence Grant from the National Institute of Aging!

August 2013
Congratulations to Dennis Anderson and the Framingham Team for a new manuscript assessing the assoication between QCT-based vertebral bone measurements and vertebral fracture. Link to Paper

May 2013
Congratulations to Jordan Spatz for being awarded the Hugh Hampton Young Fellowship in support of his graduate studies at the Harvard-MIT Division of Health Sciences and Technology.

May 2013
Congratulations to Mary Bouxsein for being awarded the ESCEO-IOF Herbert Fleisch Medal in honor of her work in the field of skeletal fragility.

April 2013
Congratulations to Dr. Dennis Anderson for his promotion to Instructor of Orthopedic Surgery in the Department of Orthopedic Surgery at Harvard Medical School!

April 2013
Congratulations to Rachell Ellman and Jordan Spatz for their papers on the mechanical regulation of bone in the April issue of JBMR. Link to Rachel's Paper and Jordan's Paper.

February 2013
Congratulations to Alex Bruno for being runner up in the NSBRI Graduate Student Poster Competition at the NASA Human Research Program Investigators' Workshop. His poster explores how individual variation in spinal curvature and muscle morphology influence in vivo estimates of spinal loading: [Alex's Poster]

December 2012
The Bouxsein Lab wishes everyone the Merriest of Holidays and Joy in the New Year!

November 2012
Congratulations to Rachel Ellman for her publication investigating the relationship between skeletal loading and bone mass and architecture: Link to Paper 1

October 2012
Congratulations to Jordan Spatz for his recent publications investigating the link between sclerostin and skeletal loading: Link to Paper 1, Link to Paper 2

September 2012
Lab member Clara De Paolis has been selected as one of the 2012 BIDMC Latino Achievement Award Honorees for her work to promote math and science education among underserved minority communities in the Boston area and nationally. The Latino Achievement Award Ceremony will take place on October 3rd, 2012, from 12:00 to 1:00 p.m., in the Rabkin Boardroom on Shapiro 10. Congratulations Clara!

August 2012
Congratulations to following lab members for accepted presentations at ASBMR:

Tamara Rozental et al, “Poor Bone Microarchitecture in Premenopausal Women with Recent Distal Radius Fracture Persists after Adjusting for Ultradistal Radius BMD” (plenary poster)

Rachel Ellman et al, “Site- and compartment-specific effects of microgravity on the skeleton in mice flown on the STS-135 shuttle mission” (oral presentation)

Mary Bouxsein et al, “Association of prevalent vertebral fractures with bone density and strength at the thoracic and lumbar spine in men and women” (poster)

Mary Bouxsein et al, “Sclerostin Antibody Treatment Improves Bone Mass, Microarchitecture and Mechanical Properties in Mice Exposed to Microgravity: Results from the STS-135 Shuttle Mission” (oral presentation)

Lamya Karim et al, “Reference Point Indentation Measures Are Associated with Whole Bone Mechanical Properties Independent of Geometry” (poster)

Dennis Anderson et al, “Association of Spinal Extensor Muscle Size and Density with Thoracic Kyphosis” (poster)

Maureen Devlin et al “Early onset Type 2 diabetes impairs skeletal acquisition in the Tallyho mouse” (plenary poster)

August 2012
Congrats to Lamya Karim on being awarded a T32 Training Grant for Translational Research in Aging from BIDMC/Harvard!

August 2012
A warm welcome to Dan Brooks and Clara De Paolis, the most recent members of the Bouxsein Lab!

August 2012
Congratulations to Dennis Anderson and Alex Bruno for presentatons at the American Society of Biomechanics annual meeting.

July 2012
Congratulations to Microindentation team for receiving a 1 year grant from Merck to investigate the etiology of atypical femoral fractures.

July 2012
Congrats to Maureen Devlin for accepting her new position as assistant professor of anthropology at the University of Michigan! You will be missed!

June 2012
Congrats to Rachel Ellman for receiving the American Institute of Aeronautics and Astronautics Orville and Wilbur Wright Graduate Award!

May 2012
Harvard Medicine Magazine article on space-related research being conducted by Harvard faculty members, including our STS-135 experiment looking at bone loss in mice: Space Savers

May 2012
Congratulations to Framingham team for manuscript in JBMR reporting the link between thoracic kyphosis, whole-body posture, and vertebral loading: Link to Paper

May 2012
Harvard Magazine trailer for an upcoming article on space-related research being conducted by Harvard faculty members, including our STS-135 experiment looking at bone loss in mice: Space Savers

March 2012
Congratulations to Rachel Ellman and Jordan Spatz for representing the Harvard-MIT Bioastronautics Program at the official opening of the National Space Biomedical Research Institute and Baylor College of Medicine's Center for Space Medicine. The new facility will be used by biomedical researchers to better understand the human health risks associated with long duration space flight, and to develop countermeasures and technologies to mitigate those risks. Also in attendance were Senator Hutchison of Texas, the director of NASA Johnson Space Center Mike Coats, and the director of the NSBRI Jeffrey Sutton. More information on the center can be found here: Area researchers work to keep astronauts healthy in space

February 2012
Congratulations to Alex Bruno and Jordan Spatz for winning 3rd and 5th place in the poster competition at the NASA Human Research Program Investigators' Workshop!

December 2011
Volunteer Decorating at Christmas time through the Harpoon Brewery
Harpoon Volunteer Decorating

October, 2011
Congratulations to Dennis Anderson and Framingham team for manuscript in Journal of Biomechanics reporting trunk muscle regressions for spine modeling [PDF]

September, 2011
Congratulations to Yoo Mee Kim and others for article accepted in Osteoporosis International !
Kim YM, Demissie S, Genant HK, Cheng X, Yu W, Samelson EJ, Kiel DP, Bouxsein ML. Identification of prevalent vertebral fractures using CT lateral scout views: a comparison of semi-automated quantitative vertebral morphometry and radiologist semi-quantitative grading. Accepted by Osteoporosis International, September 2011.

September, 2011
Good luck to John D'Agostino and former lab member Alison Cloutier as they start grad school.

August, 2011
Congratulations to Sean Serell for new job at Conformist!

August, 2011
Congratulations to Sneh Shah for his new job at Terumo!

June, 2011
Check out Devlin and Bouxsein article in special issue of BONE: Bone, Fat and Brain [PDF]

June 29, 2011
Going away / good luck party for Alison, who is leaving the lab to begin a PhD program in Mechanical Engineering at MIT. A fun evening at La Verdad. Good luck Alison!

alison with book three people
group photo mouseketeers

June 20, 2011
Congratulations to all the folks who have presentations at the ASBMR annual meeting in San Diego this September: Jordan Spatz (oral presentation and young investigator award!!), Maureen Devlin, PhD (plenary poster), Dennis Anderson, PhD (plenary poster), Ben Roberts (poster) and Yoo Mee Kim, MD, PhD (poster). Well done!

June 16, 2011
Congratulations to Sean Serell for passing his master's thesis defense in Biomedical Engineering at Boston University! Yay.

June 15, 2011
Great lecture at Orthopedic Grand Rounds this morning by astronaut and orthopedic surgeon, Robert Satcher, MD. See all his groupies…
robert satcher at grand rapids

May 23, 2011
Congratulations to Alex Bruno on passing his PhD qualifying exam in the MIT-Health Sciences and Technology Bioastronautics Program!

May 5, 2011
Lab trip to weekday afternoon game at the RedSox! (too bad the Sox lost…)
red sox game

April 2011
Congratulations to Maureen Devlin, PhD, who was promoted to Instructor of Orthopedic Surgery at Harvard Medical School!

April 2011
Congratulations to Alex Bruno for his first conference oral presentation at the GRIBOI annual meeting in Boston.

March 2011
Congratulations to John D'Agostino for being accepted into graduate programs at Northeastern and Tufts!

March 2011
Congratulations to Alison Cloutier on the news that she was awarded an NSF Graduate Fellowship!

February 2011
Congratulations to Rachel Ellman for her award for outstanding student poster at the 18th Annual IAA Humans in Space Conference! [link]


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